研究方向：	食用菌遗传育种 食用菌营养生理与形态发育分子机理研究
		职    称：	副教授
		电子邮件：	yuhaosunshine@163.com
		个人网页：	https://www.mushroomlab.cn/yuhao

博士，副教授，硕士生导师，毕业于上海交通大学微生物代谢国家重点实验，目前为青岛农业大学生命科学学院“食用菌精准育种实验室”Co-PI，团队科研工作负责人。主要从事（1）食用菌遗传育种研究；（2）食用菌营养生理和形态发育分子机理研究；（3）基于质谱的组学技术研究。主持国家自然基金面上项目、国家自然基金青年项目、山东省自然基金、山东省良种工程、青岛市东协作项目等多个科研项目。发表论文64篇，其中在《J Hazard Mater》《J Agric Food Chem》《Int J Biol Macromol》《Food Sci Hum Well》《J Biol Chem》等杂志上发表英文SCI论文52篇。

1. 学术型硕士：生物学

2. 专业型硕士：生物与医药

1. 通讯地址：山东省青岛市城阳区长城路700号青岛农业大学生命科学学院/科技楼6033

2. 电子邮件：yuhaosunshine@163.com

2019.12~至今，青岛农业大学，生命科学学院，微生物学系，副教授。

2023.03~2023.09，上海市农业科学院，食用菌研究所，访问学者，导师：谭琦研究员。

2019年~2019年，美国密西根州里大学，微生物与分子遗传系，访问学者，导师：Robert P. Hausinger教授。

2015年~2019年，青岛农业大学，生命科学学院，微生物学系，讲师，硕士生导师。

2009年~2015年，上海交通大学，生命科学技术学院，微生物学，博士研究生，导师：许平教授。

2005年~2009年，山东大学，生命科学学院，生物技术专业，理学学士。

1. 蛋白激酶A GlPKA参与CO2控制灵芝LZ015子实体形态发育的分子机制研究，2023年1月1日-2026年12月31日，国家自然科学基金面上项目，主持。

2. 优质高效食用菌新品种选育，2022年11月-2025年12月，山东省良种工程项目，主持（子课题）。

3. 省重点实验室平台项目-基于大数据的食用菌特色种质及活性成分的研发与示范，2021年12月-2024年12月，山东省重点研发项目，主持（子课题）。

4. 科技特派员行动计划项目-大球盖菇大棚高效栽培技术示范与应用，2022年8月-2024年8月，中央引导地方科技发展专项-科技成果转移转化，主持。

5. 垃圾渗滤液中联苯、二苯并呋喃的微生物矿化研究，2016年7月-2018年7月，山东省自然科学基金青年基金项目，主持。

6. 假单胞菌LY1降解3-吲哚乙酸上游途径分子机理研究，2017年1月-2019年12月，国家自然科学基金青年科学基金项目，主持。

7. 工厂化白色真姬菇新品种选育及产权保护，2018年11月-2020年10月，横向项目，主持。

Shuxue Zhao, Xiaohang Li, Xingdong Yao, Wei Wan, Lili Xu, Lizhong Guo, Jie Bai, Chunhui Hu*, Hao Yu*. Transformation of antibiotics to non-toxic and non-bactericidal products by laccases ensure the safety of Stropharia rugosoannulata. J Hazard Mater. 2024, (accepted)

Zhang Y†, Mao C†, Liu X, Guo L, Hu C, Li X, Xu L*, Yu H*. Insights into Evolution and Heat stress responsive mechanisms through whole genome sequencing and comparative proteomics analysis of the domesticated edible mushroom Lepista sordida. Mycology. 2024 (accepted) (10.1080/21501203.2024.2363620)

Zhao S, Li X, Yao X, Liu X, Pan C, Guo L, Bai J, Chen T, Yu H*, Hu C*. Detoxification of tetracycline hydrochloride and synthetic dyes by a newly characterized Lentinula edodes laccase, and safety assessment using proteomic analysis. Ecotox Environ Safe. 2024, 276:116324

Zhu L†, Su Y†, Ma S, Guo L, Yang S*, Yu H*. Comparative proteomic analysis reveals candidate pathways related to the effect of different light qualities on the development of mycelium and fruiting body of Pleurotus ostreatus. J Agric Food Chem. 2024, 72: 1361-1375

Yu G, Ge X, Wang Y, Mo X, Yu H, Tan L, Yang S. Discovery of novel terpenoids from the Basidiomycete Pleurotus ostreatus through genome mining and coculture optimization. J. Agric. Food Chem. 2023, 71, 11110-11123.

Yang X, Liu M, Zhang Y, Guo L, Wang J, Li S, Zhang Y, Li X, Xu L*, Yu H*. Comparative proteomics analysis reveals the domesticated Lepista sordida primordium differentiation regulation mechanism and the subsequent different development patterns in the pileus and stipe. Food Sci. Hum. Well. 2024 (accepted)

Yu H†, Jiang N†, Yan M†, Cheng X, Zhang L, Zhai D, Liu J, Zhang M, Song C, Yu H*, Li Q*. Comparative analysis of proteomes and transcriptomes revealed the molecular mechanism of development and nutrition of Pleurotus giganteus at different fruiting body development stages. Front. Nutr. 2023, 10,1197983.

Yang X, Li S, Li X, Zhang C, Liu M, Guo L, Liu L*, Yu H*. Comparative proteomics reveals the response and adaptation mechanisms of white Hypsizygus marmoreus against the biological stress caused by Penicillium. Food Sci. Hum. Well. 2024, 13:1109-1117

Xu L†, Yang W†, Qiu T, Gao X, Zhang H, Zhang S, Cui H, Guo L, Yu HL*, Yu H*. Complete genome sequences and comparative secretomic analysis for the industrially cultivated edible mushroom Lyophyllum decastes reveals insights on evolution and lignocellulose degradation potential. Front. Microbiol. 2023, 14:1137162

Liu L†, Jin X†, Lu X, Guo L, Lu P, Yu H*, Lv B*. Mechanisms of surfactin from Bacillus subtilis SF1 against Fusarium foetens: a novel pathogen inducing potato wilt. J. Fungi 2023, 9, 367.

Liping Zhu†, Xia Gao†, Meihua Zhang, , Chunhui Hu, Wujie Yang, Lizhong Guo, Song Yang, Hailong Yu*, and Hao Yu*. Whole genome sequence of an edible mushroom Oudemansiella raphanipes (Changgengu). Journal of Fungi, 2023, 9(2), 266.

Liping Zhu, Yao Su, Zhiheng Ma, Lizhong Guo, Song Yang*, Hao Yu*. Comparative Proteomic Analysis Reveals Differential Protein Expression of Hypsizygus marmoreus in Response to Different Light Qualities.  International Journal of Biological Macromolecules, 2022

Hailong Yu†, Meiyan Zhang†, Yating Sun, Qiaozhen Li, Jianyu Liu, Chunyan Song, Xiaodong Shang, Qi Tan, Lujun Zhang* and Hao Yu*. Whole Genome Sequence of an High Temperature Edible Mushroom Pleurotus giganteus (Zhudugu). Frontiers in Microbiology, 2022, 13:941889

Rongmei Lin§, Lujun Zhang§, Xiuqing Yang, Qiaozhen Li, Chenxiao Zhang, Lizhong Guo, Hao Yu*, Hailong Yu*. Responses of the mushroom Pleurotus ostreatus under different CO₂ concentration by comparative proteomic analyses. Journal of Fungi, 2022, 8, 652

Shuxue Zhao, Chao Pan, Junxing Zhao, Haiyan Du, Min Li, Hao Yu*, Xi Chen*. Quantitative Proteomic Analysis of the Microbial Degradation of 3-Aminobenzoic Acid by Comamonas sp. QT12. Scientific Reports, 2022, 12, 17609.

Li S†, Zhao S†, Hu C, Mao C, Guo L, Yu HL*, and Yu H*. Whole genome sequence of an edible mushroom Stropharia rugosoannulata (Daqiugaigu). Journal of Fungi, 2021, 8(2), 99

Yang XQ†, Lin RM†, Xu K, Guo LZ and Yu H*. Comparative proteomic analysis within the developmental stages of the mushroom white Hypsizygus marmoreus. Journal of Fungi, 2021, 7, 1064

Zhao SX†, Chen X†, Sun QS, Wang F, Hu CH, Guo LZ, Bai J, Yu H*. Label-Free quantitative proteomic analysis of the global response to indole-3-acetic acid in newly isolated Pseudomonas sp. strain LY1. Frontiers in Microbiology 2021, 12, 694874

Xu L, Guo LZ, Yu H*. Label-free comparative proteomics analysis revealed heat stress responsive mechanism in Hypsizygus marmoreus. Frontiers in Microbiology 2021, 11, 541967

Wang W, Li Q, Zhang L, Cui J, Yu H, Wang X, Ouyang X, Tao F, Xu P, Tang H. Genetic mapping of highly versatile and solvent-tolerant Pseudomonas putida B6-2 (ATCC BAA-2545) as a ‘superstar’ for mineralization of PAHs and dioxin-like compounds. Environmental Microbiology 2021, 23(8): 4309-4325.

Jiang C, Ji J, Li P, Liu W, Yu H, Yang X, Guo Li, Fan, Y. New lanostane-type triterpenoids with proangiogenic activity from the fruiting body of Ganoderma applanatum. Natural Product Research, 2021, 36(6): 1529-1535

Xu L, Gao J, Guo L, Yu H*. Heat shock protein 70 (HmHsp70) from Hypsizygus marmoreus confers thermotolerance to tobacco. AMB Express 2020, 10, 12

Yang T, Shao YH, Guo LZ, Meng XL, Yu H, Lu WD. Role of N,N-Dimethylglycine and its catabolism to sarcosine in Chromohalobacter salexigens DSM 3043. Applied and Environmental Microbiology 2020, 86 (17), e01186-20

Yu H, Zhao S, Fan Y, Hu C, Lu W, Guo L. Cloning and heterologous expression of a novel halo/alkali-stable multi-domain xylanase (XylM(18)) from a marine bacterium Marinimicrobium sp. strain LS-A18. Applied Microbiology and Biotechnology. 2019, 103(21-22):8899-8909

Wang G, Xu L, Yu H, Gao J, Guo L*. Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum. BMC Genomics. 2019, 20(1):585

Zhao S†, Hu C†, Guo L, Li K*, Yu H*. Isolation of a 3-hydroxypyridine degrading bacterium, Agrobacterium sp. DW-1, and its proposed degradation pathway. AMB Express. 2019, 9:65

Hu C†, Zhao S†, Li K, Yu H*. Microbial degradation of nicotinamide by a strain Alcaligenes sp. P156. Scientific Reports. 2019, 9(1):3647

Shao Y, Guo L, Zhang Y, Yu H, Zhao B, Pang H, Lu W*. Glycine betaine monooxygenase, an unusual Rieske-type oxygenase system, catalyzes the oxidative N-demethylation of glycine betaine in Chromohalobacter salexigens DSM 3043. Applied and Environmental Microbiology. 2018, 84(13):e00377-18

Yu H*, Zhao S, Lu W, Wang W, Guo L*. A novel gene, encoding 3-aminobenzoate 6-monooxygenase, involved in 3-aminobenzoate degradation in Comamonas sp. strain QT12. Applied Microbiology and Biotechnology. 2018, 102:4843–4852

Yu H*, Zhao S, Guo L*. Novel gene encoding 5-aminosalicylate 1,2-dioxygenase from Comamonas sp. Strain QT12 and catalytic properties of the purified enzyme. Journal of Bacteriology. 2018, 200(1):e00395-17

Shao Y, Guo L, Yu H, Zhao B, Lu W. Establishment of a markerless gene deletion system in Chromohalobacter salexigens DSM 3043. Extremophiles. 2016, 21: 839–850

Yu H, Tang H, Li Y, Xu P. Molybdenum-containing nicotine hydroxylase genes in a nicotine degradation pathway that is a variant of the pyridine and pyrrolidine pathways. Applied and Environmental Microbiology. 2015, 81: 8330-8338

Yu H., Tang H, Zhu X, Li Y, Xu P. Molecular mechanism of nicotine degradation by a newly isolated strain, Ochrobactrum sp. Strain SJY1. Applied and Environmental Microbiology. 2014, 81: 272–281

Yu H, Hausinger R, Tang H, Xu P. Mechanism of the 6-hydroxy-3-succinoyl-pyridine 3-monooxygenase flavoprotein from Pseudomonas putida S16. The Journal of Biological Chemistry. 2014, 289: 29158–29170

Yu, H., Tang, H. & Xu, P. Green strategy from waste to value-added-chemical production: efficient biosynthesis of 6-hydroxy-3-succinoyl-pyridine by an engineered biocatalyst. Scientific Reports. 2014, 4: 5397

Yu, H., Li, Y., Tang, H. & Xu, P. Genome sequence of a newly isolated nicotine-degrading bacterium, Ochrobactrum sp. SJY1 Genome announcements. 2014, 2: e00720-14

Wang, L., Tang H., Yu, H., Yao, YX. & Xu, P. An unusual repressor controls the expression of a crucial nicotine-degrading gene cluster in Pseudomonas putida S16 Molecul. Microbiol. 2014, 91: 1252–1269

Qu, Y.†, Zhang, X.†, Yu, H.† (Co-author), Tang, H.† Shen, E, Zhou, H., Ma, Q., Cao, X., Zhou, JT. & Xu, P. Genome sequence of Sphingomonas xenophaga QYY, an anthraquinone-degrading strain. Genome announcements. 2013, 1: e00031-12

Tang, H., Wang, L.†, Wang W.†, Yu, H.†, Zhang, K., Yao, Y. & Xu, P. Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas. PLoS Genet. 2013, 9: e1003923

Yao Y., Tang H., Ren H., Yu, H., Wang, L., Zhang, W., Behrman, E. & Xu, P. Iron(II)-dependent dioxygenase and N-formylamide deformylase catalyze the reactions from 5-hydroxy-2-pyridone to maleamate. Sci. Rep. 2013, 3: 3235

Xu, P., Yu, H., Chakrabarty, A. & Xun, LY. Genome sequence of the 2,4,5-Trichlorophenoxyacetate-degrading bacterium Burkholderia phenoliruptrix strain AC1100. Genome announcements. 2013, DOI: 10.1128/genomeA.00600-13

Yao, Y., Tang, H., Ren, H., Yu, H., Wang, L. & Xu, P. Genome sequence of a nicotine-degrading strain of Arthrobacter. J. Bacteriol. 2012, 194: 5714–5715

Liu, X., Gai, Z., Tao, F., Yu, H., Tang, H. & Xu, P. Genome sequences of Pseudomonas luteola XLDN4-9 and Pseudomonas stutzeri XLDN-R, two efficient carbazole-degrading strains. J. Bacteriol. 2012, 194: 5701–5702

Liu, X., Gai, Z., Tao, F., Yu, H., Jiang, T., Dou, P., Wang, Y., Qin, T., Lv, M. & Xu, P. Genome sequence of the lactate-utilizing Pseudomonas aeruginosa strain XMG. J. Bacteriol. 2012, 194: 4751–4752

Ma, Q.†, Qu, Y.†, Tang, H.†, Yu, H.† (Co-author), Ma, F., Shi, SN., Zhang, XW., Zhou, H., Zhou, JT. & Xu, P. Genome sequence of a novel indigo-production strain, Pseudomonas monteilii QM. J. Bacteriol. 2012, 194: 4459–4460.

Tang, H.†, Yu, H.† (Co-author), Tai, C., Huang, K., Liu, Y., Wang, L., Yao, Y., Wu, G. & Xu, P. Genome sequence of a novel nicotine-degrading strain, Pseudomonas geniculata N1. J. Bacteriol. 2012, 194: 3553–3554

Tang, H., Yao, Y., Wang, L., Yu, H., Ren, Y., Wu, G. & Xu, P. Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation. Sci. Rep. 2012, 2: 377

Tang, H.†, Yu, H.† (Co-author), Li, Q.†, Wang, X., Gai, Z., Yin, G., Su, F., Tao, F., Ma, C. & Xu, P. Genome sequence of Pseudomonas putida strain B6-2, a superdegrader of polycyclic aromatic hydrocarbons and dioxin-like compounds. J. Bacteriol. 2011, 193: 6789–6790

Yu, H., Tang, H., Wang, L., Yao, Y., Wu, G. & Xu, P. Complete genome sequence of the nicotine-degrading Pseudomonas putida strain S16. J. Bacteriol. 2011,193: 5541–5542

Tang, H., Yao, Y.†, Zhang, D.†, Meng, X.†, Wang, L.†, Yu, H.†, Ma, L. & Xu, P. A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. J. Biol. Chem. 2011, 286: 39179–39187

孙倩姝, 赵书雪, 徐康, 白洁, 于浩, 胡春辉*. 菌株Alcaligenes sp. P156中一个新型烟酸羟化酶的克隆与功能验证. 中国海洋大学学报（自然科学版） 2022, 52(01)

孙倩姝, 白洁, 李辉, 于浩, 胡春辉*. 混合菌群DBFC对二苯并呋喃的降解特性及其代谢途径. 微生物学报 2021, 61(11): 3357-3568

李树文, 徐丽丽, 于浩, 郭立忠*. 耐盐碱羊肚菌菌株筛选研究. 中国食用菌 2020, 39(12):6

徐丽丽, 王菲, 胡春辉, 郭立忠, 于浩*.利用荧光染色和流式细胞技术辅助长根菇原生质体制备与再生研究. 菌物学报（一级学报） 2020. 39(2): 1-12

于浩, 葛志豪, 徐丽丽, 郭立忠*. 双单杂交技术选育长根菇高品质抗病新菌株. 南方农业学报（核心期刊） 2019. 50(12):2621-2628

王菲, 胡春辉, 于浩*. 6-羟基烟酸3-单加氧酶（NicC）催化反应机理研究. 中国生物工程杂志 2019. 39(7):15-23

胡春辉, 王菲, 郭立忠, 于浩*. 产碱杆菌Alcaligenes sp.P156中龙胆酸1,2-双加氧酶GdoP的研究. 青岛农业大学学报（自然科学版） 2019. 36(3):176-182

胡春辉, 于浩, 赵阳国, 田伟君, 白洁*. 高效耐盐柴油降解菌的筛选、鉴定及降解基因. 中国环境科学（EI）2017. 37(11):4251-4258

胡春辉, 徐青, 于浩*. Arthrobacter sp. 2PR降解2-羟基吡啶动力学及降解特性研究. 中国生物工程杂志 2017. 37(8):31-38.

陈建超, 葛志豪, 徐丽丽, 于浩, 郭立忠*. 野生宽鳞多孔菌蛋白质营养分析与评价. 氨基酸和生物资源（科技核心）2016. 4:1-4.

胡春辉, 徐青, 孙璇, 于浩, 袁玉清*. 几种典型扫描电镜生物样本制备. 湖北农业科学（科技核心）2016. 55(20): 5389-5393.

李鹏鹏, 于浩, 许平, 唐鸿志*. 6-羟基-3-琥珀酰吡啶单加氧酶HspB的结构研究. 中国生物工程杂志. 2015. 35: 68−75.

胡传明, 于浩, 唐鸿志, 吴更, 许平. 6-羟基-3-琥珀酰吡啶单加氧酶纯化与结晶条件研究. 微生物学通报 2014. 41: 1779−1784.

1. 于浩, 胡春辉, 郭立忠. 一种长根菇SSR分子标记引物及其应用. 授权公告日：2022年5月20日. 专利号ZL 202110150625.6

2. 于浩, 贾毅, 郭立忠, 徐丽丽. 一株菇健白玉菇GJ7菌株及其SSR标记引物和应用. 授权公告日：2022年6月10日. 专利号：ZL202010998461.8

生物保藏信息CCTCC M 2020473 2020.09.07。

3. 于浩, 贾毅, 郭立忠, 徐丽丽. 一株菇健蟹味菇GJ5菌株及其SSR标记引物和应用. 授权公告日：2022年5月13日. 专利号：ZL 202010998551.7。

4. 于浩, 胡春辉. 农杆菌及其在降解3-羟基吡啶中的应用. 授权公告日：2020年8月14日. 专利号：ZL 2019 1 0179193.4

5. 胡春辉, 于浩, 白洁. 一株不动杆菌及其在石油降解中的应用. 授权公告日：2020年12月8日. 专利号：ZL 2017 1 0388369.8

6. 胡春辉, 于浩, 白洁. 一株高效降解2-羟基吡啶的球型节杆菌菌株HCH-1及其菌剂制备方法与应用. 授权公告日：2018年02月27日. 专利号：ZL 201710041644.9.